In a preprint on biorxiv,. This monoclonal antibody, generated against paired helical filaments (phfs) isolated from alzheimer’s brains, recognizes tau phosphorylated at serine 202. Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including alzheimer’s disease.
Tau Techno Mechanicus, el nuevo hijo de Elon Musk con Grimes
No information is available about the. It showed that apoe3ch clings onto tau. Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of alzheimer’s disease.
This isoform degrades quickly and resists phosphorylation and aggregation.
Many research groups study tau misfolding and propagation using in vitro models, but interpreting findings from artificial systems can be dicey. To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time.
